| Bioactivity | SH-5 is a potent AKT inhibitor. SH-5 potentiates the apoptosis induced by tumor necrosis factor. SH-5 blocks NF-kB activation induced by TNF-a, lipopolysaccharide (HY-D1056), phorbol ester (HY-18739), and cigarette smoke[1]. |
| Invitro | SH-5 (5 µM; 4+24 h) 可增强 1 nM TNF 在 H1299 细胞中的细胞毒性[1]。SH-5 (5 µM; 4+0、6、12、18、24 h) 可增强肿瘤坏死因子 (TNF) 在 H1299 细胞中诱导的细胞凋亡[1]。SH-5 (1、3、5 µM) 以剂量依赖性方式抑制 TNF (1 nM; 24 h) 诱导的 COX-2 基因表达[1]。SH-5 (5 µM; 4+0, 6, 12, 18, 24 h) 以时间依赖性方式降低 KBM-5 细胞中 1 nM TNF 诱导的 IAP-1、XIAP、Bcl-Xl、Bcl-2、TRAF1、Survivin、COX-2、Cyclin D1、MMP-9 的蛋白表达[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> SH-5 相关抗体: Western Blot Analysis[1] Cell Line: |
| CAS | 701976-54-7 |
| Formula | C29H59O10P |
| Molar Mass | 598.75 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sethi G, et al. SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation. Biochem Pharmacol. 2008 Dec 1;76(11):1404-16. |