| Bioactivity | SH-42 is a potent and selective inhibitor of human Δ24-dehydrocholesterol reductase (DHCR24), with an IC50 of 42 nM. SH-42 can lead to a significant increase in plasma desmosterol levels of mice[1]. | |||||||||
| Target | IC50: 42 nM (DHCR24) | |||||||||
| Name | SH-42 | |||||||||
| CAS | 2143952-36-5 | |||||||||
| Formula | C25H38O4 | |||||||||
| Molar Mass | 402.57 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Müller C, et, al. New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase. Eur J Med Chem. 2017 Nov 10;140:305-320. |