| Bioactivity | SB 258741 hydrochloride is a specific 5-HT7 receptor antagonist and can be used for the research of schizophrenia[1]. |
| Invitro | SB-258741 behaves as a partial inverse agonist, the antagonist potency (apparent pKB) is 8.47[2]. |
| In Vivo | SB 258741 (0-9.1 mg/kg; s.c.; once or daily for 3 days) shows antipsychotic effects in rats[1]. Animal Model: |
| Name | SB 258741 hydrochloride |
| Formula | C19H31ClN2O2S |
| Molar Mass | 386.98 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Pouzet B, et al. Effects of the 5-HT(7) receptor antagonist SB-258741 in animal models for schizophrenia. Pharmacol Biochem Behav. 2002 Apr;71(4):655-65. [2]. Mahé C, et al. Differential inverse agonist efficacies of SB-258719, SB-258741 and SB-269970 at human recombinant serotonin 5-HT7 receptors. Eur J Pharmacol. 2004 Jul 14;495(2-3):97-102. |