| Bioactivity | FGFR-IN-3 (compound 6) is an orally active, potent and BBB-penetrated FGFR (fibroblast growth factor receptor) modulator. FGFR-IN-3 shows neuroprotective activity. FGFR-IN-3 can be used for neurodegenerative diseases research[1]. |
| In Vivo | FGFR-IN-3 (compound 6) is sufficiently lipophilic (logP = 2.2) to passively permeate across the blood-brain barrier, and further increase in molecular lipophilicity results in boosting MBI (mechanism-based inactivation) activity[1]. |
| Name | FGFR-IN-3 |
| CAS | 2488762-63-4 |
| Formula | C18H27F2N5O2 |
| Molar Mass | 383.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sakai H, et al. Fibroblast growth factor receptor modulators employing diamines with reduced phospholipidosis-inducing potential. Bioorg Med Chem. 2020 Jul 15;28(14):115562. |
FGFR-IN-3
CAS: 2488762-63-4 F: C18H27F2N5O2 W: 383.44
FGFR-IN-3 (compound 6) is an orally active, potent and BBB-penetrated FGFR (fibroblast growth factor receptor) modulator
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