| Bioactivity | S65487 (VOB560) hydrochloride, a potent and selective Bcl-2 inhibitor, is a prodrug of S55746. S65487 hydrochloride is also active on BCL-2 mutations, such as G101V and D103Y. S65487 hydrochloride has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 hydrochloride induces apoptosis and has anticaner activities[1][2]. |
| Invitro | S65487 hydrochloride binds to the BH3 hydrophobic groove of BCL-2. S65487 hydrochloride induces apoptosis in a panel of hematological cancer cell lines and inhibits cell proliferation with IC50s in the low nM range[1]. |
| Name | S65487 hydrochloride |
| CAS | 1644543-95-2 |
| Formula | C41H42Cl2N6O4 |
| Molar Mass | 753.72 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
S65487 hydrochloride
CAS: 1644543-95-2 F: C41H42Cl2N6O4 W: 753.72
S65487 (VOB560) hydrochloride, a potent and selective Bcl-2 inhibitor, is a prodrug of S55746. S65487 hydrochloride is a
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