| Bioactivity | Bomedemstat (IMG-7289) dihydrochloride is an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor. Bomedemstat dihydrochloride can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat dihydrochloride shows anti-cancer activities, inhibits cancer cell proliferation and induces apoptosis[1][2]. |
| Invitro | Bomedemstat dihydrochloride 通过同时增加 p53 的表达和甲基化选择性抑制Jak2V617F 细胞增殖并诱导其凋亡[1]。Bomedemstat (50 nM-1 μM; 96 h; SET-2 细胞) dihydrochloride 提高存活率，以 TP53 依赖性方式通过 BCL-XL 和 PUMA 诱导细胞凋亡，并导致细胞周期停滞[1]。 Apoptosis Analysis[1] Cell Line: |
| Name | Bomedemstat dihydrochloride |
| Formula | C28H36Cl2FN7O2 |
| Molar Mass | 592.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Bomedemstat dihydrochloride
CAS: F: C28H36Cl2FN7O2 W: 592.54
Bomedemstat (IMG-7289) dihydrochloride is an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibit
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