| Bioactivity | S29434 (NMDPEF) is a potent, competitive, selective and cell-permeable inhibitor of quinone reductase 2 (QR2), with IC50s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1. S29434 induces autophagy and inhibits QR2-mediated ROS production[1]. | ||||||||||||
| Target | IC50: 5 nM (h QR2, expressed in E. coli, NRH as co-substrate), 16 nM (h QR2, expressed in E. coli, with BNAH as co-substrate) | ||||||||||||
| Invitro | S29434 (5-10 μM; 24 h) induces HepG2 cells autophagy[1]. Cell Autophagy Assay[1] Cell Line: | ||||||||||||
| In Vivo | S29434 (1 and 15 mg/kg; i.p. once) affects object recognition memory in vivo[1]. Animal Model: | ||||||||||||
| Name | S29434 | ||||||||||||
| CAS | 874484-20-5 | ||||||||||||
| Formula | C21H18N4O3 | ||||||||||||
| Molar Mass | 374.39 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Boutin JA, et al. S29434, a Quinone Reductase 2 Inhibitor: Main Biochemical and Cellular Characterization. Mol Pharmacol. 2019 Mar;95(3):269-285. |