| Bioactivity | LY2940094 (BTRX-246040) is a potent, selective and orally available nociceptin receptor (NOP receptor) antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY2940094 reduces ethanol self-administration in animal models[1]. | |||||||||
| Target | Ki: 0.105 nM (NOP receptor)Kb: 0.166 nM (NOP receptor) | |||||||||
| In Vivo | LY2940094 (3, 10, or 30 mg/kg; 2-3 mL/kg; orally daily; for 4 days) dose-dependently reduces homecage ethanol self-administration in Indiana Alcohol-Preferring (P) and Marchigian Sardinian Alcohol-Preferring (msP) rats, without affecting food/water intake or locomotor activity[1]. Animal Model: | |||||||||
| Name | LY2940094 | |||||||||
| CAS | 1307245-86-8 | |||||||||
| Formula | C22H23ClF2N4O2S | |||||||||
| Molar Mass | 480.96 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
|
|||||||||
| Reference | [1]. Rorick-Kehn LM, et al. A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models. Alcohol Clin Exp Res. 2016 May;40(5):945-54. |
LY2940094
CAS: 1307245-86-8 F: C22H23ClF2N4O2S W: 480.96
LY2940094 (BTRX-246040) is a potent, selective and orally available nociceptin receptor (NOP receptor) antagonist with h
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.