S1R agonist 2 hydrochloride_product_DataBase

Bioactivity	S1R agonist 2 (Compound 8b) hydrochloride is a selective S1R agonist with Kis of 1.1 nM and 88 nM for S1R and S2R, respectively. S1R agonist 2 hydrochloride exhibits neuroprotection against ROS and NMDA-induced neurotoxicity[1].
Target	Ki: 1.1 nM and 88 nM for S1R and S2R
Invitro	S1R agonist 2 (Compound 8b; 0.1-5 μM) hydrochloride 均能显著增加神经生长因子 (NGF) 诱导的神经突生长，且呈剂量依赖性[1]。S1R agonist 2 (24 h) hydrochloride 在 SHSY5Y 细胞中浓度为 1 μM 时对 Rotenone (HY-B1756) 诱导的细胞损伤有显著的抑制作用[1]。S1R agonist 2 (0.1-5 μM; 24 h) hydrochloride 在 SHSY5Y 细胞中对 NMDA 刺激有神经保护作用[1]。S1R agonist 2 (0-10 μM; 24-72 h) hydrochloride 对 A549、LoVo 和 Panc-1 细胞无细胞毒性[1]。 0 --> S1R agonist 2 hydrochloride 相关抗体:
In Vivo	S1R agonist 2 (Compound 8b; 0.1-50 μM; 120 h) hydrochloride 在 10 μM 浓度下不诱导胚胎死亡 (100%存活胚胎)，但在最高剂量 (50 μM) 下诱导所有胚胎死亡[1]。
Name	S1R agonist 2 hydrochloride
Formula	C21H28ClNO
Molar Mass	345.91
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Linciano P, et al. Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents. Eur J Med Chem. 2023 Mar 5;249:115163.

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