| Bioactivity | S1PR1 modulator 1 is a selective S1PR1 inhibitor, with a pIC50 of 7.6, with >40- and >80-fold selectivity, over the other S1PR isoforms S1PR2/3/4[1]. |
| Target | pIC50: 7.6 (S1PR1), 6 (S1PR3) |
| Invitro | S1PR1 modulator 1 (Compound 10a; (Z,Z)-10a) is selective at S1PR1 over S1PR3 (pIC50, 6), S1PR2 and S1PR4 (pIC50s, <5)[1]. |
| Name | S1PR1 modulator 1 |
| CAS | 2328109-05-1 |
| Formula | C23H24N2O3S |
| Molar Mass | 408.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bell M, et al. Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1). ACS Med Chem Lett. 2019 Feb 14;10(3):341-347. |
S1PR1 modulator 1
CAS: 2328109-05-1 F: C23H24N2O3S W: 408.51
S1PR1 modulator 1 is a selective S1PR1 inhibitor, with a pIC50 of 7.6, with >40- and >80-fold selectivity, over the othe
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