| Bioactivity | MRS1177 is a potent and selective human Adenosine A3 receptor (hA3AR) antagonist, with a Ki of 0.3 nM. |
| Target | Ki: 0.3 nM (hA3AR). |
| Invitro | MRS1177 (compound 2b) is a potent and selective human Adenosine A3 receptor (hA3AR) antagonist[1]. The Ki value of MRS1177 (compound 55) with hA3AR is 0.3 nM[2]. |
| Name | MRS1177 |
| CAS | 183721-13-3 |
| Formula | C20H12ClN5O2 |
| Molar Mass | 389.79 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tafi A, et al. Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models. J Med Chem. 2006 Jul 13;49(14):4085-97. [2]. Cheong SL, et al. Pharmacophore elucidation for a new series of 2-aryl-pyrazolo-triazolo-pyrimidines as potent human A3 adenosine receptor antagonists. Bioorg Med Chem Lett. 2011 May 15;21(10):2898-905. |