| Bioactivity | S-F24 is an antifungal agent with excellent broad-spectrum. S-F24 inhibits CYP3A4 with an IC50 value of 0.4 μM. S-F24 displays a good safety profile with high selectivity, low hemolytic effects, and low tendency to induce resistance. S-F24 can be used for research on fungal infections[1]. |
| Invitro | S-F24 (10-30 μM，48 h) 对哺乳动物细胞的毒性较弱[1]。S-F24 (0.002 μg/mL，20 passages) 对抗 C. albicans SC5314 的 MIC80 值增加 8 倍[1]。S-F24 (0.004 μg/mL，16 h) 在 C. albicans SC5314 中抑制麦角甾醇合成达 92.03%[1]。 Cell Cytotoxicity Assay[1] Cell Line: |
| In Vivo | S-F24 (1，5 mg/kg，i.p.，5 天，每天一次) 在雌性 IRC 小鼠中广泛应用于处理 C. albicans SC5314， A. fumigatus CGMCC3.7795，和 耐药 C. albicans 24D 的真菌侵袭性感染[1]。S-F24 (0.5，1 mg/kg，i.p.，5 天，每天一次) 在雌性 IRC 小鼠中抑制皮肤感染 C. albicans SC5314 非常有效[1]。 Animal Model: |
| Name | S-F24 |
| Formula | C25H27BrF2N6O |
| Molar Mass | 545.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhu P, et al. Novel Triazoles with Potent and Broad-Spectrum Antifungal Activity In Vitro and In Vivo. J Med Chem. 2023 Jun 8;66(11):7497-7515. |