| Bioactivity | MAO-B-IN-4 (Compound 26) is an orally active and reversible MAO-B inhibitor with an IC50 of 9 nM. MAO-B-IN-4 has good metabolic stability, safety profile and brain permeability. MAO-B-IN-4 shows antidepressant activity in rats and mice. MAO-B-IN-4 can be used in studies related to Alzheimer's disease[1]. |
| Invitro | MAO-B-IN-4 (0.25 μM 24 小时暴露于 0.5μM DOX 中) 在培养的星形胶质细胞模型中显示了明显的神经胶质保护作用[1]。 Cell Viability Assay[1] Cell Line: |
| In Vivo | MAO-B-IN-4 (1 和 3 mg/kg, 口服, 2 h) 可以防止东莨菪碱引起的短期记忆障碍[1]。MAO-B-IN-4 (0.312-2.5 mg/kg, 静脉注射, 1 h) 在强迫游泳试验中表现出小鼠抗抑郁的特性[1]。 Animal Model: |
| Name | MAO-B-IN-4 |
| Formula | C23H20ClF2N3 |
| Molar Mass | 411.87 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Grychowska K, et al. Overcoming undesirable hERG affinity by incorporating fluorine atoms: A case of MAO-B inhibitors derived from 1 H-pyrrolo-[3,2-c]quinolines. Eur J Med Chem. 2022 Jun 5;236:114329. |