S-Adenosyl-L-methionine

CAS: 29908-03-0 F: C15H22N6O5S W: 398.44

S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a die

Contact QiTai

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research[1][2][3].
Invitro	S-Adenosyl-L-methionine (300 µM, 24 或 48 h) 诱导细胞凋亡，并促进 Cal-33 和 JHU-SCC-011 细胞的细胞周期停滞[4]。S-Adenosyl-L-methionine (300 µM, 24 h) 减少 Cal-33 和 JHU-SCC-011 细胞的迁移[4]。S-Adenosyl-L-methionine (5-40 μg/mL, 48 h) 通过调节 DNMTs 的表达保护 5‑FU 的抗癌作用[5]。 Apoptosis Analysis[4] Cell Line:
In Vivo	S-Adenosyl-L-methionine (30 mg/kg，口服，持续 3 天) 可预防幼鼠出生后早期丙戊酸暴露引起的 ASD 样行为[6]。S-Adenosyl-L-methionine (50 和 100 mg/kg，口服) 在戊四唑诱导的大鼠癫痫模型中表现出抗癫痫、记忆增强和抗氧化特性[7]。 Animal Model:
Name	S-Adenosyl-L-methionine
CAS	29908-03-0
Formula	C15H22N6O5S
Molar Mass	398.44
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Reference	[1]. G M Bressa. S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14. [2]. Wadie I Najm, et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. BMC Musculoskelet Disord. 2004 Feb 26;5:6. [3]. Shelly C Lu, et al. S-adenosylmethionine in liver health, injury, and cancer. Physiol Rev. 2012 Oct;92(4):1515-42. [4]. Mosca L, et al. Effects of S‑adenosyl‑L‑methionine on the invasion and migration of head and neck squamous cancer cells and analysis of the underlying mechanisms. Int J Oncol. 2020 May;56(5):1212-1224. [5]. Ham MS, et al. S-adenosyl methionine specifically protects the anticancer effect of 5-FU via DNMTs expression in human A549 lung cancer cells. Mol Clin Oncol. 2013 Mar;1(2):373-378. [6]. Ornoy A, et al. S-adenosyl methionine prevents ASD like behaviors triggered by early postnatal valproic acid exposure in very young mice. Neurotoxicol Teratol. 2019 Jan-Feb;71:64-74. [7]. Dhediya RM, et al. Evaluation of antiepileptic effect of S-adenosyl methionine and its role in memory impairment in pentylenetetrazole-induced kindling model in rats. Epilepsy Behav. 2016 Aug;61:153-157.

Onalespib lactate