| Bioactivity | AC-90179 is a selective 5-HT2A receptor inverse agonist (Ki = 2.1 nM) and 5-HT2C antagonist, a potential antipsychotic compound[1]. |
| In Vivo | AC-90179（1-10 mg/kg, i.p., 30 min）在 C57BL/6小鼠中完全逆转 DOI（0.3-3 mg/kg i.p.，15 min）诱导的反应率抑制，而在较低剂量的 AC-90179（1 mg/kg, i.p., 30 min）下，仅观察到部分逆转 DOI 诱导的抑制[1]。AC-90179（1 或3 mg/kg，s.c.）可减轻苯环利定（3 mg/kg, i.p., 15 min）诱导的 NSA小鼠多动症[1]。 |
| Name | AC-90179 |
| CAS | 359878-19-6 |
| Formula | C23H31ClN2O2 |
| Molar Mass | 402.96 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kimberly E. Vanover, et al. Pharmacological Characterization of AC-90179 [2-(4-Methoxyphenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide Hydrochloride]: A Selective Serotonin 2A Receptor Inverse Agonist. Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 943-951 |
AC-90179
CAS: 359878-19-6 F: C23H31ClN2O2 W: 402.96
AC-90179 is a selective 5-HT2A receptor inverse agonist (Ki = 2.1 nM) and 5-HT2C antagonist, a potential antipsychotic c
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