| Bioactivity | S 1360 is a potent and selective inhibitor of HIV-1 integrase. S-1360 inhibits the catalytic activity of purified integrase (IC50: 20 nM). The EC50, and CC50 of S 1360 in MTT assay (MT-4 cells infected with HIV-1 IIIB) are 200 nM and 12 μM, respectively. S 1360 has antiviral activity against both X4 tropic and R5 tropic strains, as well as NRTI, NNRTI and PI drug-resistant variants[1]. |
| CAS | 280571-30-4 |
| Formula | C16H12FN3O3 |
| Molar Mass | 313.28 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Neamati N. Patented small molecule inhibitors of HIV-1 integrase: a 10-year saga[J]. Expert Opinion on Therapeutic Patents, 2002, 12(5): 709-724. |