| Bioactivity | FPPS-IN-2 (compound 4a) is a potent and orally active HFPPS inhibitor with an IC50 value of 1.108 µM. FPPS-IN-2 has the potential for the research of osteoporosis[1]. |
| Target | IC50: 1.108 µM (HFPPS) |
| In Vivo | FPPS-IN-2 (compound 4a) (0.1, 1, 10 mg/kg; p.o.; daily for 8 weeks) 在卵巢切除大鼠中显示出抗骨质疏松功效[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C24H26O6 |
| Molar Mass | 410.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. El-Sayed NF, et al. Farnesyl pyrophosphate synthase inhibitors with antiosteoporosis efficacy in ovariectomized rats: A mixed binding approach beyond bisphosphonates. Eur J Med Chem. 2024 Jul 14;276:116679. |