| Bioactivity | Rustmicin (Galbonolide A) is a potent antifungal agent. Rustmicin inhibits inositol phosphoceramide synthase. Rustmicin shows antifungal activity[1]. |
| Invitro | Rustmicin (0-32 µg/mL; 24-48 h) 显示抗真菌活性，对 Cryptococcus neoformans MY1051, Cryptococcus neoformans MY1146, Cryptococcus neoformans MY2061, Cryptococcus neoformans MY2062, C. parapsilosis (MY1010), C. pseudotropicalis (MY2099), C. krusei (MY549), C. tropicalis (MY1012) 菌株的 MIC 值分别为 0.002, 0.001, 0.0001, 0.0002, 0.015, 0.015, 0.031, 0.031 µg/mL[1]。 |
| In Vivo | Rustmicin (0、10、20、40、80 mg/kg；腹腔注射；每天两次，持续 4 天) 在隐球菌病小鼠模型中显示出抗真菌活性[1]。 Animal Model: |
| Name | Rustmicin |
| CAS | 100227-57-4 |
| Formula | C21H32O6 |
| Molar Mass | 380.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mandala SM, et al. Rustmicin, a potent antifungal agent, inhibits sphingolipid synthesis at inositol phosphoceramide synthase. J Biol Chem. 1998 Jun 12;273(24):14942-9. |