Anti-infective agent 4_product_DataBase

Bioactivity	Anti-infective agent 4 (compound 73) is an orally active inhibitor of Trypanosoma cruzi with an IC50 value of 0.016 μM. Anti-infective agent 4 effectively reduces parasite burden in vivo. Anti-infective agent 4 can be used for the research of infection[1].
Target	IC50: 0.016 μM (Trypanosoma cruzi)
Invitro	Anti-infective agent 4 (0.1 nM-100 μM; 48 h) shows antitrypanosomal activity against T. cruzi amastigotes in 3T3 cells with an IC50 value of 0.016 μM[1]. Cell Cytotoxicity Assay[1] Cell Line:
In Vivo	Anti-infective agent 4 (50 mg/kg; p.o. once daily for five days) reduces the parasite burden in bioluminescent T. cruzi mouse model[1]. Animal Model:
Name	Anti-infective agent 4
CAS	2738381-52-5
Formula	C19H12F3N5O4
Molar Mass	431.32
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Ang CW, et al. Nitroimidazopyrazinones with Oral Activity against Tuberculosis and Chagas Disease in Mouse Models of Infection. J Med Chem. 2022 Sep 16.

PeptideDB