Robalzotan hydrochloride

CAS: 184674-99-5 F: C18H24ClFN2O2 W: 354.85

Robalzotan hydrochloride (NAD-299 hydrochloride) is a potent and selective 5-Hydroxytryptamine 1A (5-HT1A) inhibitor.

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Bioactivity	Robalzotan hydrochloride (NAD-299 hydrochloride) is a potent and selective 5-Hydroxytryptamine 1A (5-HT1A) inhibitor. Robalzotan hydrochloride increases the firing rate of 5-HT cells. Robalzotan hydrochloride induces 5-HT1A receptor occupancy. Robalzotan hydrochloride has the potential for the research of a cholinergic deficit in the central -nervous system[1][2][3].
In Vivo	Robalzotan hydrochloride (1-100 µg/kg；i.v.) 在大鼠体内以 5 µg/kg 显着增加此类神经元的活性，并逆转 citalopram (HY-121203) (300 µg/kg i.v.) 或 paroxetine (HY-122272) (100 µg/kg， i.v.) 对大鼠中缝背核 5-HT神经元活性的影响[1].Robalzotan hydrochloride (5, 50 µg/kg；静脉注射) 提高 5-HT 细胞的放电率[1]。Robalzotan hydrochloride (2-100 µg/kg; i.v.) 在猴子体内以剂量依赖性方式占据 5-HT1A 受体[2]。Robalzotan hydrochloride (0.3；1 和 3 µmol/kg 皮下注射) 引起大鼠 FC 细胞外 ACh 水平的剂量依赖性增加[3]。 Animal Model:
Name	Robalzotan hydrochloride
CAS	184674-99-5
Formula	C18H24ClFN2O2
Molar Mass	354.85
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Arborelius L, et al. The 5-HT(1A) receptor antagonist robalzotan completely reverses citalopram-induced inhibition of serotonergic cell firing. Eur J Pharmacol. 1999 Oct 8;382(2):133-8. [2]. Farde L, et al. PET-Determination of robalzotan (NAD-299) induced 5-HT(1A) receptor occupancy in the monkey brain. Neuropsychopharmacology. 2000 Apr;22(4):422-9. [3]. Hu, Xiao Jing, et al. Modulation of acetylcholine release by serotonergic 5-HT1A and 5-HT1B receptors : a microdialysis study in the awake rat. 2007.