| Bioactivity | Cl-HIBO is a highly subtype-selective GluR1/2 agonist (EC50=4.7 and 1.7 μM, respectively). Cl-HIBO is a potent AMPA receptor agonist (IC50=0.22 μM). Cl-HIBO has desensitizing properties[1]. |
| Target | EC50: 4.7, 1.7, 2700 and 1300 μM=GluR1/2/3/4 |
| Invitro | Cl-HIBO is a strongly desensitizing full agonist at GluR1[1]. |
| Name | Cl-HIBO |
| CAS | 909400-43-7 |
| Formula | C6H7ClN2O4 |
| Molar Mass | 206.58 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bjerrum EJ, et al. Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). J Med Chem. 2003;46(11):2246-2249. |