| Bioactivity | Ro 24-5913 (Cinalukast) is an orally active and potent LTD4 antagonist with an IC50 value of 6.4 nM. Ro 24-5913 can be used for the research of asthma[1]. |
| Target | IC50: 6.4 nM (LTD4) |
| Invitro | Ro 24-5913 competes with [3H]LTD4 for its binding site in guinea pig lung membranes with an IC50 value of 6.4 nM[1].Ro 24-5913 shows effective antagonist efficacy to LTD4-induced contractions with a pKB value of 9.3[1]. |
| In Vivo | Ro 24-5913 (10 mg/kg i.v. and 100 mg/kg p.o.; once) inhibits LTD4-induced bronchoconstriction in guinea pigs with LD50s of 0.13 and 0.12 mg/kg for i.v. and p.o. respectively[1]. Animal Model: |
| Name | Ro 24-5913 |
| CAS | 128312-51-6 |
| Formula | C23H28N2O3S |
| Molar Mass | 412.55 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. O'Donnell M. Ro 24-5913: a potent, specific, orally active LTD4 antagonist. Ann N Y Acad Sci. 1991;629:413-5. |
Ro 24-5913
CAS: 128312-51-6 F: C23H28N2O3S W: 412.55
Ro 24-5913 (Cinalukast) is an orally active and potent LTD4 antagonist with an IC50 value of 6.4 nM. Ro 24-5913 can be u
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