COX-2-IN-16

CAS: 1610894-92-2 F: C19H12BrN3O2 W: 394.22

COX-2-IN-16 (compound 2b) is a potent, selective and orally active COX-2 inhibitor with an IC50 of 102 µM. COX-2-IN-16

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Bioactivity	COX-2-IN-16 (compound 2b) is a potent, selective and orally active COX-2 inhibitor with an IC50 of 102 µM. COX-2-IN-16 inhibits the NO production. COX-2-IN-16 shows anti-inflammatory activity[1].
In Vivo	COX-2-IN-16 (compound 2b) (100 mg/kg; p.o.) shows better reduction in the edema formation by 42% in a rat paw edema model[1].
Name	COX-2-IN-16
CAS	1610894-92-2
Formula	C19H12BrN3O2
Molar Mass	394.22
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. García-Aranda MI, et al. Anti-inflammatory effect and inhibition of nitric oxide production by targeting COXs and iNOS enzymes with the 1,2-diphenylbenzimidazole pharmacophore. Bioorg Med Chem. 2020 May 1;28(9):115427.