| Bioactivity | Reverse transcriptase-IN-3 is a pyrimidine-5-carboxamide derivative, acts as an inhibitor of HIV-1. Reverse transcriptase-IN-3 shows potent activity against the HIV-1 wild-type and mutant strains[1]. |
| Invitro | Reverse transcriptase-IN-3 (化合物21c) (EC50=0.009-0.065 μM) 对 HIV-1 IIIB (8 nM)、L100I (65 nM)、K103N (9 nM)、Y181C (45 nM)、Y188L (35 nM) 和 RES056 (42 nM) 的抑制活性最强，与 Etravirine (HY-90005) 相当[1]。 |
| Name | Reverse transcriptase-IN-3 |
| Formula | C28H31N7O4S |
| Molar Mass | 561.66 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Feng D, et al. Disubstituted pyrimidine-5-carboxamide derivatives as novel HIV-1 NNRTIs: Crystallographic overlay-based molecular design, synthesis, and biological evaluation. Eur J Med Chem. 2022 Nov 22;246:114957. |
Reverse transcriptase-IN-3
CAS: F: C28H31N7O4S W: 561.66
Reverse transcriptase-IN-3 is a pyrimidine-5-carboxamide derivative, acts as an inhibitor of HIV-1. Reverse transcriptas
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