Rasagiline-13C3 mesylate_product_DataBase

Bioactivity	Rasagiline-13C3 ((R)-AGN1135-13C3; TVP1012-13C3) mesylateis the deuterium labeledRasagiline (mesylate)(HY-14605)[1]. Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC50s of 4.43?nM and 412?nM for rat brain MAO B and A activity, respectively[2].
Invitro	氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。
Name	Rasagiline-13C3 mesylate
CAS	1391052-18-8
Formula	C1013C3H17NO3S
Molar Mass	270.32
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

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