| Bioactivity | RU28362 is a potent and selective glucocorticoid agonist. RU28362 increases the Bnip3 mRNA levels in neurons. RU28362 inhibits adrenocorticotrophic hormone (ACTH) and corticosterone secretion[1][2]. |
| Invitro | RU28362 (0.1、1、5、10 nM; 72 小时) 会以剂量依赖性方式增加神经元中的 Bnip3 mRNA 水平[1]。 RT-PCR[1] Cell Line: |
| In Vivo | RU28362 (150 µg/kg；腹腔注射) 可抑制促肾上腺皮质激素 (ACTH) 和皮质酮的分泌，并选择性抑制应激诱导的垂体前叶 POMC hnRNA 增加[2]。 Animal Model: |
| Name | RU28362 |
| CAS | 74915-64-3 |
| Formula | C23H28O3 |
| Molar Mass | 352.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sandau US, et al. Glucocorticoids exacerbate hypoxia-induced expression of the pro-apoptotic gene Bnip3 in the developing cortex. Neuroscience. 2007 Jan 19;144(2):482-94. [2]. Ginsberg AB, et al. Specific and time-dependent effects of glucocorticoid receptor agonist RU28362 on stress-induced pro-opiomelanocortin hnRNA, c-fos mRNA and zif268 mRNA in the pituitary. J Neuroendocrinol. 2006 Feb;18(2):129-38. |