| Bioactivity | MC4033 shows IC50s of 39.4 μM, 52.1 μM, 41 μM and 30.1 μM in HCT116, H1299, A549 and U937, respectively[1].MC4033 (25, 50, 100, and 200 μM, 72 h) reduces the level of H4K16Ac in HT29 cells, suggesting its ability to inhibit KAT8 in cells[1]. | ||||||||||||
| Target | 12.1μM (lysine acetyltransferase 8, KAT8) | ||||||||||||
| Invitro | MC4033 (25, 50, 100 和 200 μM, 72 小时) 降低了 HT29 细胞中 H4K16Ac 的表达水平，表明其能够抑制细胞中的 KAT8 的表达水平[1]。MC4033 在 HCT116， H1299， A549 和 U937 细胞中测得的 IC50 值分别为 39.4 μM, 52.1 μM, 41 μM和 30.1 μM[1]。 Cell Proliferation Assay[1] Cell Line: | ||||||||||||
| Name | MC4033 | ||||||||||||
| Formula | C16H13N3O3 | ||||||||||||
| Molar Mass | 295.29 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Fiorentino F, et al. First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8. J Med Chem. 2023 May 25;66(10):6591-6616 |