| Bioactivity | RU 59063 is an N-substituted arylthiohydantoin compound with antiandrogenic activity and high relative binding affinity for the rat androgen receptor. RU 59063 is a nonsteroidal androgen receptor that functions as a radioactive AR radioprobe (Ki: 0.71 nM, rAR) when its trifluoromethyl group is replaced by a similar hydrophobic iodine atom[1][2]. |
| CAS | 155180-53-3 |
| Formula | C17H18F3N3O2S |
| Molar Mass | 385.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Teutsch G, et al. Non-steroidal antiandrogens: synthesis and biological profile of high-affinity ligands for the androgen receptor. J Steroid Biochem Mol Biol. 1994 Jan;48(1):111-9. [2]. Van Dort ME, et al. Design, synthesis, and pharmacological characterization of 4-[4, 4-dimethyl-3-(4-hydroxybutyl)-5-oxo-2-thioxo-1-imidazolidinyl]- 2-iodobenzonitrile as a high-affinity nonsteroidal androgen receptor ligand. J Med Chem. 2000 Aug 24;43(17):3344-7. |
RU 59063
CAS: 155180-53-3 F: C17H18F3N3O2S W: 385.40
RU 59063 is an N-substituted arylthiohydantoin compound with antiandrogenic activity and high relative binding affinity
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