NADH disodium hydrate

CAS: 1949720-50-6 F: C21H29N7O14P2.xH2O.2Na W:

NADH disodium salt (Disodium NADH) hydrate is an orally active reduced coenzyme. NADH disodium salt hydrate is a donor o

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Bioactivity	NADH disodium salt (Disodium NADH) hydrate is an orally active reduced coenzyme. NADH disodium salt hydrate is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. NADH disodium salt hydrate plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle[1].
Invitro	NADH is unstable under acidic conditions but it is stable under alkaline conditions[2].NADH (0-1 mM; 0-12 h) increases NAD+ levels in various mammalian cell lines[3].NADH (1 mM; 24 h) causes low toxicity and protects cells from genotoxicity[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> NADH disodium hydrate 相关抗体:
In Vivo	NADH (5 μmol/mouse; i.p.; once) increases urinary excretion of nicotinamide and its metabolites in mice[2].NADH (500 mg/kg; i.g.; once) promotes alcohol metabolism and prevents or ameliorates early liver injury caused by acute alcohol exposure in ethanol-loaded mice[3].NADH (1000 mg/kg; i.p.; once) enhances tissue NAD+ levels in male C57BL/6J mice[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	1949720-50-6
Formula	C21H29N7O14P2.xH2O.2Na
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Ying W. NAD+ and NADH in cellular functions and cell death. Front Biosci. 2006 Sep 1;11:3129-48. [2]. Kimura N, et al. Comparison of metabolic fates of nicotinamide, NAD+ and NADH administered orally and intraperitoneally; characterization of oral NADH. J Nutr Sci Vitaminol (Tokyo). 2006 Apr;52(2):142-8. [3]. Wu K, et al. NADH and NRH as potential dietary supplements or pharmacological agents for early liver injury caused by acute alcohol exposure. Journal of Functional Foods, 2021, 87: 104852.