| Bioactivity | RO5527239 is an orally active TGR5 agonist, that induces a stimulatory response from intestinal L cells and specificially secrets the endogenous hormone GLP-2[1]. |
| In Vivo | RO5527239 (30 mg/kg，口服 10 天) 刺激 TGR5 受体，上调 L 细胞以及由 L 细胞分泌的 GLP-2，触发 C57BL/6N 小鼠 GLP-2 依赖性的肠道适应[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 1354812-99-9 |
| Formula | C28H31N3O3 |
| Molar Mass | 457.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hunt JE, et al., Pharmacological activation of TGR5 promotes intestinal growth via a GLP-2-dependent pathway in mice. Am J Physiol Gastrointest Liver Physiol. 2020 May 1;318(5):G980-G987. |
RO5527239
CAS: 1354812-99-9 F: C28H31N3O3 W: 457.56
RO5527239 is an orally active TGR5 agonist, that induces a stimulatory response from intestinal L cells and specificiall
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