Anticancer agent 193

CAS: F: C34H47ClN2O6 W: 615.20

Anticancer agent 193 (compound D3-3) is an inducer of ferritinophagy, eventually triggering ferroptosis. Anticancer agen

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Bioactivity	Anticancer agent 193 (compound D3-3) is an inducer of ferritinophagy, eventually triggering ferroptosis. Anticancer agent 193 induces the production of lipid ROS, and significantly promoted colorectal cancer cells to release the ferrous ion in an autophagy-dependent manner[1].
Invitro	Anticancer agent 193 (D3-3；2.5-30 μM；12-48 h) 抑制 HCT-116 细胞增殖，在 12、24 和 48 h 时的 IC50 值分别为 15.06 μM， 11.18 μM 和 5.87 μM[1]。Anticancer agent 193（D3-3；5-20 μM；12 小时）显着增加自噬标记蛋白 LC3B-II/LC3B-I 比率。它还能增强铁蛋白亚基 FTH1 的表达[1]。Anticancer agent 193（D3-3；5-20 μM；12 h）有效促进脂质 ROS 的积累[1]。Anticancer agent 193 (D3-3) 以浓度依赖性方式显着增加 HCT-116 细胞中的二价铁水平[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Anticancer agent 193 相关抗体: Cell Proliferation Assay[1] Cell Line:
In Vivo	Anticancer agent 193（D3-3；30-60 mg/kg；腹腔注射；每天；持续 2 周）在 HCT-116 异种移植模型中抑制肿瘤生长并促进脂质过氧化[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
Formula	C34H47ClN2O6
Molar Mass	615.20
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Ling Zhu, et al. Identification of a ferritinophagy inducer via sinomenine modification for the treatment of colorectal cancer. Eur J Med Chem. 2024 Feb 21:268:116250.