| Bioactivity | RO27-3225 is a peptide agonist of melanocortin receptor 4 (MC4R) with neuroprotective and anti-inflammatory activity with an EC50 value of 1 nM, while 8 nM for MC1R. RO27-3225 Ro 27-3225 reverses hemorrhagic shock, reduces brain edema, blood-brain barrier (BBB) permeability, and hippocampal IL-1β and TNF-α levels in a rat model of intra-abdominal hypertension induced by hemorrhagic shock and resuscitation[1][2]. |
| CAS | 1373926-49-8 |
| Formula | C41H53F3N12O8 |
| Molar Mass | 898.93 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Liu D, et al. Melanocortin MC4 receptor agonists alleviate brain damage in abdominal compartment syndrome in the rat. Neuropeptides. 2015 Feb;49:55-61. [2]. Benoit SC, et al. A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences. J Neurosci. 2000 May 1;20(9):3442-8. |
RO27-3225 trifluoroacetate
CAS: 1373926-49-8 F: C41H53F3N12O8 W: 898.93
RO27-3225 is a peptide agonist of melanocortin receptor 4 (MC4R) with neuroprotective and anti-inflammatory activity wit
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