| Bioactivity | RNF5-IN-1 (FX12) is a selective RNF5 degrader. RNF5-IN-1 binds to RNF5 and inhibits its E3 activity, and promotes proteasomal degradation of RNF5 in an endoplasmic reticulum (ER)-associated degradation (ERAD) way in cells. RNF5-IN-1 inhibits α-1-antitrypsin (NHK) dislocation with an IC50 value of 2.7 μM. RNF5-IN-1 can be used for research of cystic fibrosis, acute myeloid leukemia, and certain viral infections[1]. |
| CAS | 1807639-36-6 |
| Formula | C10H8O4S |
| Molar Mass | 224.23 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ruan J, et al. A small-molecule inhibitor and degrader of the RNF5 ubiquitin ligase. Mol Biol Cell. 2022 Nov 1;33(13):ar120. |