| Bioactivity | RK-0133114 is a G9a inhibitor and a R-enantiomer of RK-701 (HY-152775). RK-0133114 inhibits G9a with an IC50 value of 3.7 μM. RK-0133114 can be used for the research of sickle cell disease (SCD)[1]. |
| Invitro | RK-0133114 对人脐血来源的 erythroid progenitor 2 (HUDEP-2) 细胞中 H3K9me2 的水平无影响，并且无法增加 HUDEP-2 细胞中 fetal globins (HbF)[1].RK-0133114 (0.1 nM-100 μM) 抑制 G9a 的 IC50 值为 3.7 μM[1]。 |
| Name | RK-0133114 |
| Formula | C26H30N4O3 |
| Molar Mass | 446.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Takase S, et al. A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression. Nat Commun. 2023 Jan 12;14(1):23. |