| Bioactivity | RIPK2/3-IN-1 is a potent dual RIPK2/3 kinases inhibitor with IC50 values of 3 nM and 117 nM, respectively. RIPK2/3-IN-1 is against RIPK2 with IC50 value 14?±?4 nM in 14-TriLAN-Gly/NOD1 THP-1 cell-based NF-κB reporter assay[1]. |
| Name | RIPK2/3-IN-1 |
| Formula | C24H16N4O2S2 |
| Molar Mass | 456.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mbilo Misehe, et al. Exploring positions 6 and 7 of a quinazoline-based scaffold leads to changes in selectivity and potency towards RIPK2/3 kinases .Eur J Med Chem. 2023 Nov 15;260:115717. |