| Bioactivity | Pro-905 is a phosphite peptide with antitumor activity. Pro-905 delivers the active nucleotide antimetabolite thioguanosine monophosphate (TGMP) to the tumor. Pro-905 effectively prevents incorporation of purine salvage substrates into nucleic acids and inhibits colony formation in human malignant peripheral nerve sheath tumors (MPNST) cells. Pro-905 inhibits purine salvage incorporation to nucleic acids and prevents cell growth. Pro-905 inhibits the growth of MPNST and enhances the anti-tumor efficacy of JHU395 (HY-124778) [1]. |
| Invitro | Pro-905 (10 µM, 120 h) 与JHU395 (1 µM, 120 h) 联合用药抑制 JH-2-002 细胞增殖和鸟嘌呤并入新合成的 DNA 和 RNA [1]。Pro-905 (10 µM, 120 h) 与 JHU395 (1 µM, 120 h) 联合用药可抑制 sNF96.2 和 JH-2-002 人 MPNST 细胞的集落形成[1]。Pro-905 (10 µM, 6 h) 在 sNF96.2 细胞中对嘌呤依赖性 3H-次黄嘌呤与 DNA 和 RNA 的结合有抑制作用[1]。 0 --> PRO-905 相关抗体: Cell Proliferation Assay[1] Cell Line: |
| In Vivo | Pro-905 (20 mg/kg, 腹腔注射, 每周5天给药, 持续4周) 在携带人 MPNST PDX JH-2-031 的 NSG 小鼠模型中减缓了肿瘤的生长[1]。Pro-905 (10 mg/kg, 腹腔注射, 一周5天给药) 与 JHU395 (1.2 mg/kg, p.o.) 联合用药在 B6 翼侧 MPNST 小鼠模型中抑制肿瘤核苷酸代谢，抑制 MPNST 增殖[1]。 Animal Model: |
| Name | PRO-905 |
| Formula | C22H29N6O8PS |
| Molar Mass | 568.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lemberg KM,et al. Pro-905, a novel purine antimetabolite, combines with glutamine amidotransferase inhibition to suppress growth of malignant peripheral nerve sheath tumor. Mol Cancer Ther. 2023 Aug 24:MCT-23-0258. |