| Bioactivity | RIP2 kinase inhibitor 1 (compound 11) is a potent and selective receptor interacting protein 2 (RIP2) kinase inhibitor with an IC50 of 0.03 μM for RIP2 FP. RIP2 kinase inhibitor 1 is used for autoinflammatory disorders[1]. |
| Target | IC50: 0.03 μM (RIP2) |
| Invitro | RIP2 kinase inhibitor 1 (compound 11) inhibits human whole blood (hWB; IC50=0.05 μM), activin receptor-like kinase 5 (ALK5; IC50>10 μM), VEGFR2 (IC50=7.94 μM), lymphocyte-specific protein tyrosine kinase (LCK; IC50=31.6 μM)[1]. |
| Name | RIP2 kinase inhibitor 1 |
| CAS | 2380028-10-2 |
| Formula | C17H17N5O2S |
| Molar Mass | 355.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Haffner CD, et al. Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors.ACS Med Chem Lett. 2019 Oct 11;10(11):1518-1523. |
RIP2 kinase inhibitor 1
CAS: 2380028-10-2 F: C17H17N5O2S W: 355.41
RIP2 kinase inhibitor 1 (compound 11) is a potent and selective receptor interacting protein 2 (RIP2) kinase inhibitor w
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