| Bioactivity | RI-OR2, a retro-inverso peptide, is an amyloid-β (Aβ) oligomerization inhibitor. RI-OR2 binds to immobilized β-Amyloid (1-42) (HY-P1363A) monomers and fibrils, with an apparent Kd of 9-12 μM, and also acted as an inhibitor of Aβ(1-42) fibril extension[1]. |
| Invitro | RI-OR2 可显著逆转 Aβ(1-42) 对培养的 SH-SY5Y 神经母细胞瘤细胞的毒性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> RI-OR2 相关抗体: |
| CAS | 1219627-58-3 |
| Sequence | Ac-{d-Arg}-Gly-{d-Phe}-{d-Phe}-{d-Val}-{d-Leu}-{d-Lys}-Gly-{d-Arg}-NH2 |
| Shortening | Ac-{d-Arg}-G-{d-Phe}-{d-Phe}-{d-Val}-{d-Leu}-{d-Lys}-G-{d-Arg}-NH2 |
| Formula | C53H85N17O10 |
| Molar Mass | 1120.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mark Taylor, et al. Development of a proteolytically stable retro-inverso peptide inhibitor of beta-amyloid oligomerization as a potential novel treatment for Alzheimer's disease. Biochemistry. 2010 Apr 20;49(15):3261-72. |