RI-OR2-TAT_product_DataBase

Bioactivity	RI-OR2-TAT is a brain-penetrant inhibitor of β-Amyloid oligomerization, which is produced by adding the HIV protein transduction domain TAT to RI-OR2. RI-OR2-TAT binds to Aβ42 fibrils with a Kd value of 58-125 nM. RI-OR2-TAT reduces Aβ aggregation and plaque levels, reduces activation of microglia and oxidative damage, and increases the number of young neurons in the dentate gyrus[1].
CAS	1430219-69-4
Sequence	Ac-{d-Arg}-Gly-{d-Phe}-{d-Phe}-{d-Val}-{d-Leu}-{d-Lys}-Gly-{d-Arg}-{d-Arg}-{d-Arg}-{d-Arg}-{d-Gln}-{d-Arg}-{d-Arg}-{d-Lys}-{d-Lys}-{d-Arg}-Gly-{d-Tyr}-NH2
Shortening	Ac-{d-Arg}-G-{d-Phe}-{d-Phe}-{d-Val}-{d-Leu}-{d-Lys}-G-{d-Arg}-{d-Arg}-{d-Arg}-{d-Arg}-{d-Gln}-{d-Arg}-{d-Arg}-{d-Lys}-{d-Lys}-{d-Arg}-Gly-{d-Tyr}-NH2
Formula	C117H201N49O23
Molar Mass	2662.16
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Doig AJ, et al. Inhibition of protein aggregation and amyloid formation by small molecules. Curr Opin Struct Biol. 2015 Feb;30:50-56.

PeptideDB