| Bioactivity | RGD peptide (GRGDNP) TFA is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) TFA competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) TFA promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) TFA plays an important role in cell adhesion, migration, growth, and differentiation[1][2][3]. | ||||||
| Invitro | RGD peptide (GRGDNP) TFA (50 μM ; preincubation for 3 hours before stretch) abolishes stretch-induced IKK activation and IL-6 mRNA expression. It shows little effect on the IKK activity and IL-6 mRNA expression in unstretched HUVECs[2]. RGD peptide (GRGDNP) TFA (300 μg/mL; for 6 hours) completely reverses enhanced FN1 expression in oxygen glucose deprivation(OGD) treated primary hippocampal neurons, HT22 cell lines and in its sEVs[3]. | ||||||
| Name | RGD peptide (GRGDNP) (TFA) | ||||||
| Sequence | Gly-Arg-Gly-Asp-Asn-Pro | ||||||
| Shortening | GRGDNP | ||||||
| Formula | C25H39F3N10O12 | ||||||
| Molar Mass | 728.63 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
RGD peptide (GRGDNP) (TFA)
CAS: F: C25H39F3N10O12 W: 728.63
RGD peptide (GRGDNP) TFA is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) TFA competitively inhibit
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