| Bioactivity | RC529-MDP is a combination of Toll-like Receptor (TLR) (TLR4a) and NOD-like Receptor (NOD2a), which enhances innate immune responses. RC529-MDP induces high levels of cytokine Interleukin Related (IL-6) in a mouse model, demonstrating its effective immune-stimulating activity. RC529-MDP increases OVA-specific antibody responses, T cell responses, and the proportion of memory T cells in an OVA-injected mouse model[1]. |
| Invitro | RC529-MDP (9.3 μM，20 h) 的活性依赖于 TLR4 和 NOD2 信号通路[1]。RC529-MDP 在 Raw264.7 细胞中 CD80 和 CD86 细胞比例比 RC529 + MDP 高 1.7 倍，有效促进 APC 的成熟[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> RC529-MDP 相关抗体: |
| In Vivo | RC529-MDP 偶联物在小鼠体内使 IL-6 水平提高了 6.8 倍，导致了强有力的协同效应[1]。RC529-MDP (22.53 μg，i.p.) 在小鼠模型中体液免疫增强，同时增强了 IgG 亚型 (IgG1，IgG2a，IgG2b) 的水平[1]。RC529-MDP (22.53 μg，s.c.) 和 OVA 同时注射的小鼠模型中，适应性体液免疫快速被激活，分泌细胞因子的 T 细胞增多，产生强大的细胞免疫[1]。RC529-MDP (22.53 μg) 使中枢记忆 T 细胞 (Tcm) 比例增加，产生记忆反应[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C118H215N10O28P |
| Molar Mass | 2252.99 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Dong Ding, et al. Synergistic immune augmentation enabled by covalently conjugating TLR4 and NOD2 agonists. Eur J Med Chem. 2024 Aug 26:278:116792. |