| Bioactivity | GPX4-IN-14 (compound 2c) is an inhibitor of GPX4, with free radical scavenging activity (maximum scavenging rate is 72.52%) and anti-tumor proliferation activity in vitro. GPX4-IN-14 inhibits GPX4 protein, increases lipid peroxide levels and intracellular Reactive Oxygen Species (ROS) levels, thereby inducing ferroptosis and exerting anti-tumor proliferation effects[1]. |
| Invitro | GPX4-IN-14 (100 μM，30 min) 有良好的自由基清除活性，最大清除率为 72.52%[1]。GPX4-IN-14 在 SW480，HCT116，HepG2，MCF-7 细胞中有抗肿瘤增殖活性，IC50 为 5.61 μM，6.59 μM，18.23 μM，9.73 μM，对 LO2 的 IC50 为 11.64 μM[1]。GPX4-IN-14 (3.3，6.6，13.2 μM，24 h) 在 HCT116 中抑制 GPX4 通路，以剂量依赖性诱导细胞内 ROS 和脂质 ROS 的积累，从而导致铁死亡并抑制线粒体膜电位[1]。GPX4-IN-14 (3.3，6.6，13.2 μM，24 h) 诱导 HCT116 细胞内铁水平呈剂量依赖性升高[1]。GPX4-IN-14 (3.3，6.6，13.2 μM，24 h) 在 HCT116 中抑制 GPX4 通路[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> GPX4-IN-14 相关抗体: Immunofluorescence[1] Cell Line: |
| Formula | C26H39NO8Se |
| Molar Mass | 572.55 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Meilin Ren, et al. Design, synthesis and biological evaluation of artesunate-Se derivatives as anticancer agents by inducing GPX4-mediated ferroptosis. Bioorg Chem. 2024 Nov:152:107733. |