R-(+)-Cotinine

CAS: 32162-64-4 F: C10H12N2O W: 176.22

R-(+)-Cotinine ((+)-Cotinine), a Nicotine metabolite, lacks significant activity across a wide range of pharmacological

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Bioactivity	R-(+)-Cotinine ((+)-Cotinine), a Nicotine metabolite, lacks significant activity across a wide range of pharmacological targets. R-(+)-Cotinine can enhance the Ach-evoked current in human α7 nAChRs[1].
Invitro	R-(+)-Cotinine (1 μM) significantly enhances the Ach (40 μM)-evoked current in human α7 nAChRs[1].
In Vivo	R-(+)-Cotinine (0.3-10 mg/kg; a single i.p.) enhances the effects of a subthreshold dose of Donepezil (0.5 mg/kg) on novel object recognition (NOR) performance[1].
Name	R-(+)-Cotinine
CAS	32162-64-4
Formula	C10H12N2O
Molar Mass	176.22
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Jr AVT, et, al. R-(+) and S-(-) isomers of cotinine augment cholinergic responses in vitro and in vivo. J Pharmacol Exp Ther. 2015 Feb;352(2):405-18.