| Bioactivity | QH536 (Compound 29) is a potent HMGCR degrader with an EC50 of 0.22 μM. QH536 has no side-effect of inducing cholesterol accumulation in cells. QH536 shows anti-inflammatory and can be used for cardiovascular disease and nonalcoholic steatohepatitis research[1]. |
| Target | IC50: 0.22 μM (HMGCR) |
| Name | QH536 |
| CAS | 2754254-07-2 |
| Formula | C33H49N3O3 |
| Molar Mass | 535.76 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li XZ, et al. Synthesis of heterocyclic ring-fused analogs of HMG499 as novel degraders of HMG-CoA reductase that lower cholesterol. Eur J Med Chem. 2022 Jun 5;236:114323. |