| Bioactivity | Pyripyropene A is a potent and selective sterol O-acyltransferase 2 (SOAT2)/acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) inhibitor, with an IC50 of 0.07 µM. Pyripyropene A attenuates hypercholesterolemia and atherosclerosis in vivo[1][2][3][4]. | |||||||||
| Invitro | Pyripyropene A (0-100 µM; 72 hours) exhibits anti-proliferative activity against HUVECs, and with an IC50 value of 1.8 µM[1].Pyripyropene A (10 µM ; 24 hours) inhibits VEGF (20 ng/ml)-induced migration and tubular formation of HUVECs in dose-dependent fashion[1].Pyripyropene A do not show growth inhibitory effects against KB3-1, K562 and Neuro2A cells[1]. Cell Proliferation Assay[1] Cell Line: | |||||||||
| Name | Pyripyropene A | |||||||||
| CAS | 147444-03-9 | |||||||||
| Formula | C31H37NO10 | |||||||||
| Molar Mass | 583.63 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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Pyripyropene A
CAS: 147444-03-9 F: C31H37NO10 W: 583.63
Pyripyropene A is a potent and selective sterol O-acyltransferase 2 (SOAT2)/acyl-coenzyme A:cholesterol acyltransferase
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