| Bioactivity | Pyrimidyn 7 is an inhibitor of dynamin I/II with IC50 values of 1.1 μM and 1.8 μM, respectively. Pyrimidyn 7 competitively inhibits the interactions between GTP and phospholipids with dynamin I. Additionally, Pyrimidyn 7 reversibly inhibits clathrin-mediated endocytosis (CME) of transferrin and epidermal growth factor (EGF) in various non-neuronal cell linecell[1. |
| Target | IC50: 1.1 μM (dynamin I).IC50: 1.8 μM (dynamin II) |
| CAS | 1440126-94-2 |
| Formula | C21H41N5 |
| Molar Mass | 363.58 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. McGeachie AB, et al. Pyrimidyn compounds: dual-action small molecule pyrimidine-based dynamin inhibitors. ACS Chem Biol. 2013 Jul 19;8(7):1507-18. |
Pyrimidyn 7
CAS: 1440126-94-2 F: C21H41N5 W: 363.58
Pyrimidyn 7 is an inhibitor of dynamin I/IIwith IC50 values of 1.1 μM and 1.8 μM, respectively. Pyrimidyn 7 competitiv
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