| Bioactivity | Promethazine is an orally active histamine receptor antagonist[1]. Promethazine is first-generation antihistamine of the phenothiazine family, shows strong sedative and weak antipsychotic effects[1][2][3][4]. |
| Invitro | Promethazine (0-100 μM, 24 h) inhibits the proliferation of SW480, HCT116, HT29 and Caco2 CRC cells in a concentration-dependent manner[5]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Promethazine 相关抗体: Cell Viability Assay[5] Cell Line: |
| In Vivo | Promethazine (intraperitoneal injection; 2 mg/kg, 4 mg/kg, 6 mg/kg; once) is effective in reducing the writhing response[6]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 60-87-7 |
| Formula | C17H20N2S |
| Molar Mass | 284.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Burt DR, et al. Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain. Science. 1977 Apr 15;196(4287):326-8. [2]. Strenkoski-Nix LC, et al. Pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories and oral syrup to healthy subjects. Am J Health Syst Pharm. 2000 Aug 15;57(16):1499-505. [3]. Fiorella D, et al. The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. I: Antagonist correlation analysis. Psychopharmacology (Berl). 1995 Oct;121(3):347-56. [4]. Seeman P, et al. Dopamine D2 receptor binding sites for agonists. A tetrahedral model. Mol Pharmacol. 1985 Nov;28(5):391-9. [5]. Xinyue Tan, et al. Promethazine inhibits proliferation and promotes apoptosis in colorectal cancer cells by suppressing the PI3K/AKT pathway. Biomed Pharmacother. 2021 Nov;143:112174. [6]. Niloofar Amidi, et al. A Behavioral Study of Promethazine Interaction with Analgesic Effect of Diclofenac: Pain Combination Therapy. J Pharmacopuncture. 2020 Mar 31;23(1):18-24. |