| Bioactivity | Procaterol hydrochloride hemihydrate is an orally active β2 adrenoreceptor agonist. Procaterol hydrochloride hemihydrate can be used for the research of asthma[1][2][3]. |
| Invitro | Procaterol hydrochloride hemihydrate (0.1 μM，24-72 小时) 抑制人气管上皮细胞中的鼻病毒感染[4]。Procaterol hydrochloride hemihydrate (0-1 μg/mL, 24/48 h) 抑制 BEAS-2B 细胞中 IL-1β- 和 TNF-α 介导的嗜酸性粒细胞趋化活性[5]。Procaterol hydrochloride hemihydrate (25-200 nM, 20 h) 保护 16HBE 细胞免受 H2O2 诱导的氧化应激[6]。 |
| In Vivo | Procaterol hydrochloride hemihydrate (1、3 或 10 μg/mL，吸入给药) 抑制过敏性炎症豚鼠气道中组胺引起的气流阻塞和微血管渗漏[2]。Procaterol hydrochloride hemihydrate (0.1 mg/kg，i.p.) 完全消除有意识的豚鼠中 Mch 引起的咳嗽[3]。 Animal Model: |
| Name | Procaterol hydrochloride hemihydrate |
| CAS | 81262-93-3 |
| Formula | C16H23ClN2O3.1/2H2O |
| Molar Mass | 335.82 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Tukiainen H, et al. Comparison between oral procaterol and salbutamol in patients with bronchial asthma. Curr Med Res Opin. 1988;11(4):236-41. [2]. Mirza ZN, et al. Inhaled procaterol inhibits histamine-induced airflow obstruction and microvascular leakage in guinea-pig airways with allergic inflammation. Clin Exp Allergy. 1998 May;28(5):644-52. [3]. Ohkura N, et al. Bronchoconstriction-triggered cough in conscious guinea pigs. Exp Lung Res. 2009 May;35(4):296-306. [4]. Yamaya M, et al. Procaterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells. Eur J Pharmacol. 2011 Jan 10;650(1):431-44. [5]. Koyama S, et al. Procaterol inhibits IL-1beta- and TNF-alpha-mediated epithelial cell eosinophil chemotactic activity. Eur Respir J. 1999 Oct;14(4):767-75. [6]. Deng Z, et al. Procaterol but not dexamethasone protects 16HBE cells from H₂O₂-induced oxidative stress. J Pharmacol Sci. 2014;125(1):39-50. |
Procaterol hydrochloride hemihydrate
CAS: 81262-93-3 F: C16H23ClN2O3.1/2H2O W: 335.82
Procaterol hydrochloride hemihydrate is an orally active β2 adrenoreceptor agonist. Procaterol hydrochloride hemihydrat
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