| Bioactivity | Polyphemusin II-Derived Peptide (T140), a CXCR4 inhibitor, shows high inhibitory activity against HIV-1 entry and the inhibitory effect on the binding of an anti-CXCR4 monoclonal antibody (12G5) to CXCR4[1]. |
| Name | Polyphemusin II-Derived Peptide |
| CAS | 229030-20-0 |
| Sequence | Arg-Arg-2-Nal-Cys-Tyr-Arg-Lys-D-Lys-Pro-Tyr-Arg-Cit-Cys-Arg (Disulfide bridge:Cys4-Cys13) |
| Shortening | RRACYRKKPYR-{Cit}-CR (Disulfide bridge:Cys4-Cys13) |
| Formula | C90H141N33O18S2 |
| Molar Mass | 2037.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. H Tamamura, et al. A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140. Biochem Biophys Res Commun. 1998 Dec 30;253(3):877-82. |
Polyphemusin II-Derived Peptide
CAS: 229030-20-0 F: C90H141N33O18S2 W: 2037.42
Polyphemusin II-Derived Peptide (T140), a CXCR4 inhibitor, shows high inhibitory activity against HIV-1 entry and the in
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