Pneumolysin-IN-1_product_DataBase

Bioactivity	Pneumolysin-IN-1 (compound PB-3) is a targeted small molecule inhibitor of Pneumolysin (PLY) (IC50=3.1 µM). Pneumolysin-IN-1 is a pore blocking agent and an anti-virulence factor. Pneumolysin-IN-1 can be used to study the infection caused by Streptococcus pneumoniae[1].
Target	PLY-S61A (3.1 ± 0.4 µM), PLY-N85L (3.1± 0.6 µM), PLY-T55A (1.5± 0.5 µM), PFO (0.33 ± 0.01 µM)
Invitro	Pneumolysin-IN-1 (1，3 和 6 µM; 4 和 24 h) 显著抑制 PLY 诱导的细胞损伤，并表现出浓度依赖性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Pneumolysin-IN-1 相关抗体: Cell Viability Assay[1] Cell Line:
CAS	330842-49-4
Formula	C23H16Cl2N2O4
Molar Mass	455.29
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Aziz U B A, et al. Targeted small molecule inhibitors blocking the cytolytic effects of pneumolysin and homologous toxins[J]. Nature Communications, 2024, 15(1): 3537.

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